Waxaa laga yaabaa inaadan ka fiirsan booskaaga jirka markaad kaniiniyada qaadaneyso marka aad leedahay madax xanuun. Si kastaba ha ahaatee, cilmi-baadhis dhawaan laga sameeyay Jaamacadda Johns Hopkins waxa ay ogaatay in joogsigaagu uu si weyn u saamayn karo sida degdegga ah ee jidhkaagu u nuugo daawada, intay saacad ka dheer tahay.
Gabagabada waxay ku salaysan tahay waxa loo malaynayo inuu yahay moodalkii ugu horeeyay ee soo noqnoqda sida daroogada ugu milmo caloosha bini'aadamka.
"Waxaan aad ula yaabnay in qaabka uu u taagan yahay uu saameyn weyn ku yeesho heerka kala dirida kiniinka," ayuu yiri qoraa sare Rajat Mittal, injineer Johns Hopkins iyo khabiir ku takhasusay dhaqdhaqaaqa dareeraha. "Weligay kuma fikirin in aan saxan yahay iyo in kale, laakiin hadda hubaal waan ka fikiri doonaa mar kasta oo aan qaato kiniinka."
Natiijooyinkooda ayaa dhawaan lagu daabacay joornaalka Fisikiska dareeraha.
Sanadihii la soo dhaafay, moodooyinka si sax ah u matala shaqada xubnaha kala duwan ee muhiimka ah, gaar ahaan wadnaha, ayaa la sameeyay. Qaabka kooxda, StomachSim, wuxuu u muuqdaa mid ka mid ah kuwa ugu horreeya ee awood u leh inay sameeyaan jilitaanka dhabta ah ee caloosha bini'aadamka. StomachSim waxa ay u ekaysiisaa waxa caloosha ka dhaca marka ay cuntada kala jejebiso ama, tusaale ahaan, daawo iyada oo isku daraysa fiisigiska, biomechanics, iyo makaanikada dareeraha.
Meeshaada marka aad kaniinka qaadanayso ayaa wax wayn ka badala sida ugu dhakhsaha badan ee jidhkaagu u nuugo daawada. Credit: Khamar Hopkins/Jaamacadda Johns Hopkins
Inta badan kaniiniyada ma bilaabaan inay shaqeeyaan ilaa calooshu u gudubto waxa ku jira mindhicirka. Natiijo ahaan, mar kasta oo kaniinigu uu ku soo dhaco antrum-ka, si dhakhso ah ayuu u bilaabaa inuu burburiyo oo uu ka soo dejiyo waxa ku jira duodenum, qaybta koowaad ee mindhicirka yar. Haddii aad u hiigsanayso kaniiniga qaybtan ka mid ah caloosha, booskaagu waa muhiim si aad u isticmaasho culeyska iyo sidoo kale asymmetry ee caloosha.
Afar meelood ayaa kooxdu tijaabisay. Qaadashada kiniinka marka aad ku nasanayso dhinaca midig ayaa ah tan ugu waxtarka badan, u dirida kaniiniyada qaybta ugu qoto dheer ee caloosha iyo gaarista heerka milanka kaas oo 2.3 jeer ka dhaqso badan xitaa joog toosan. Midda ugu daran waxay ahayd dhinaca bidixda. Kooxdu waxay la yaabtay inay ogaadaan in haddii kiniinku ku milmo 10 daqiiqo dhinaca midig, waxay qaadan kartaa ilaa 23 daqiiqo meel toosan iyo in ka badan 100 daqiiqo marka la dhigo dhinaca bidixda.
Dadka da'da ah, kuwa fadhiidka ah ama kuwa sariirta jiifa, haddii ay u leexanayaan bidix ama midig waxay ku yeelan karaan saameyn weyn, "ayuu yiri Mittal.
U istaagida toosan waxay ahayd doorasho labaad oo hufan, asal ahaan waxay ku xidhan tahay waxtarka iyo jiifso toosan.
Kooxda ayaa sidoo kale tixgelisay caloosha oo aan si buuxda u shaqeyneynin sababtoo ah gastroparesis oo ay sababaan cudurrada sida sonkorowga iyo Parkinson's Syndrome ee loogu talagalay milanka kiniinka. Xitaa isbeddel yar oo ku yimaada xaaladaha caloosha waxay u horseedi kartaa kala duwanaansho weyn oo natiijada daroogada afka ah, ayuu yiri qoraaga hogaamiyaha Jae Ho "Mike" Lee, oo ah cilmi-baare hore oo postdoctoral ah oo ka tirsan Johns Hopkins.
Saamaynta cudurka caloosha ku leeyahay kala dirida maandooriyaha waxay la mid tahay ta booska-taas oo hoosta ka xariiqaysa sida farqiga u dhexeeya booska uu sameeyo.
"Boogga laftiisa ayaa saameyn weyn ku leh, waxay la mid tahay caloosha qof uu leeyahay cillad aad u weyn marka loo eego kala dirida kiniinka," ayuu yiri Mittal.
Shaqada mustaqbalka waxay isku dayi doontaa inay saadaaliso sida isbeddelada biomechanics ee caloosha ay u saameeyaan sida jidhku u nuugo daroogooyinka, sida cuntada loogu shaqeeyo caloosha, iyo saameynta booska iyo gastroparesis ee dheefshiidka cuntada.
Reference: “Computational modeling of drug dissolution in the human stomach: Effects of posture and gastroparesis on drug bioavailability” by J. H. Lee, S. Kuhar, J.-H. Seo, P. J. Pasricha and R. Mittal, 9 August 2022, Physics of Fluids.
